Selected Publications

Zinc-mediated lysosomal distablization links mitochondrial damage to neuronal death in a cellular MPP+ model of Parkinson's Disease

HS Lee, SA Kang, JW Eom, MS Kim, JS Kim, YH Kim

Journal of Neurochemistry 17 (2): e70363

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An increase of lysosomes through EGF-triggered endocytosis attenuated zinc-mediated lysosomal membrane permeabilization and neuronal cell death

JW Eom, JY Lee, YB Kwon, YH Kim

Cell Death & Disease 15 (11): 823

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S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders

KR Kim, EJ Cho, JW Eom, SS Oh, T Nakamura, C Oh, SA Lipton, YH Kim

Cell Death & Differentiation 29 (11), 2137-2150

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Zinc enhances autophagic flux and lysosomal function through transcription factor EB activation and V-ATPase assembly.

Kim KR, Park SE, Hong JY, Koh JY, Cho DH, Hwang JJ, Kim YH

Front Cell Neurosci

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The inhibition of zinc excitotoxicity and AMPK phosphorylation by novel zinc chelator, 2G11, ameliorates neuronal death induced by global cerebral ischemia.

Hong DK, Eom JW, Kho AR, Lee SH, Kang BS, Lee SH, Koh JY,

Kim YH, Suh SW Antioxidants 11 (11): 2192-2210.

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Mechanism of zinc excitotoxicity: a focus on AMPK

YH Kim, JW Eom, JY Koh

Frontiers in Neuroscience 14, 577958

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A novel zinc chelator, 1H10, ameliorates experimental autoimmune encephalomyelitis by modulating zinc toxicity and AMPK activation

BY Choi, JH Jeong, JW Eom, JY Koh, YH Kim, SW Suh

International Journal of Molecular Sciences 21 (9), 3375

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Lysosomal dysfunction in proteinopathic neurodegenerative disorders: possible therapeutic roles of cAMP and zinc

JY Koh, HN Kim, JJ Hwang, YH Kim, SE Park

Molecular Brain 12, 1-11

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Identifying new AMP-activated protein kinase inhibitors that protect against ischemic brain injury

JW Eom, TY Kim, BR Seo, H Park, JY Koh, YH Kim

ACS Chemical Neuroscience 10 (5), 2345-2354

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AMP-activated protein kinase contributes to zinc-induced neuronal death via activation by LKB1 and induction of Bim in mouse cortical cultures

JW Eom, JM Lee, JY Koh, YH Kim

Molecular Brain 9, 1-13

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Zinc preconditioning protects against neuronal apoptosis through the mitogen-activated protein kinase-mediated induction of heat shock protein 70

JM Lee, JM Lee, KR Kim, H Im, YH Kim

Biochemical and biophysical research communications 459 (2), 220-226

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Poly (ADP-ribosyl) ation of p53 contributes to TPEN-induced neuronal apoptosis

HL Kim, H Ra, KR Kim, JM Lee, H Im, YH Kim

Molecules and cells 38 (4), 312-317

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Consensus scoring approach to identify the inhibitors of AMP-activated protein kinase α2 with virtual screening

H Park, JW Eom, YH Kim

Journal of chemical information and modeling 54 (7), 2139-2146

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Zinc-triggered induction of tissue plasminogen activator and plasminogen in endothelial cells and pericytes

MK Cho, ES Sun, YH Kim

Experimental Neurobiology 22 (4), 315

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Zinc-triggered induction of tissue plasminogen activator by brain-derived neurotrophic factor and metalloproteinases

IY Hwang, ES Sun, JH An, H Im, SH Lee, JY Lee, PL Han, JY Koh, YH Kim

Journal of neurochemistry 118 (5), 855-863

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Essential role of p53 in TPEN-induced neuronal apoptosis

H Ra, HL Kim, HW Lee, YH Kim

FEBS letters 583 (9), 1516-1520

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Essential role for zinc-triggered p75NTR activation in preconditioning neuroprotection

JY Lee, YJ Kim, TY Kim, JY Koh, YH Kim

Journal of Neuroscience 28 (43), 10919-10927

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The involvement of caspase-11 in TPEN-induced apoptosis

JM Lee, YJ Kim, H Ra, SJ Kang, SJ Han, JY Koh, YH Kim

FEBS letters 582 (13), 1871-1876

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Non-proteolytic neurotrophic effects of tissue plasminogen activator on cultured mouse cerebrocortical neurons.

Kim YH, Koh JY

Exp Neurol 177(2): 407-418.

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The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly(ADP-ribose) polymerase activation and cell death in cortical culture.

Lee HY, Hwang IY, Im H, Koh JY, Kim YH

Neurochem 101: 1236-1247.

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Non-proteolytic neuroprotection by human recombinant tissue plasminogen activator.

Kim YH, Park JH, Hong SH, Koh JY

Science, 284: 647-650.

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